Dexamethasone CAS NO.50-02-2

Min.Order: 1 Kilogram
Payment Terms: T/T,

Product Details

Keywords

Dexamethasone
Dexamonozon
Dezone

Quick Details

ProName: Dexamethasone
CasNo: 50-02-2
Molecular Formula: C22H29FO5
Appearance: White crystalline solid/powder
Application: (glucocorticoid receptor) agonist
DeliveryTime: 4-12 days
PackAge: standard packaging
Port: Shanghai Tianjin Guangzhou
ProductionCapacity: 500 Metric Ton/Month
Purity: more than 97
Storage: Density 1.3 ± 0.1 g / cm3
Transportation: by sea or air
LimitNum: 1 Kilogram

Superiority

1,Best Quality:

Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so you can trust us.

2, Payment method: for example T/T, Westerm Union,other

3, Excellent Service: Best service and after-sales service to all clients.

1)We will ship the goods within 5days after get your payments.If you want to cancel or change order, please tell me within 24hours after you finish the payment..

2)We will ship the goods that you order from us by DHL, UPS, TNT and EUB.We will decided to choose which courier depend on different countries.To find the best way to delivery the goods for you.

3)As usual you can get the goods with in 4-7days.If the goods were lost or not received for other reasons, please contact us immediately.

4,Fast and safe delivery:

Sample Order : As usual you can get the goods within 4-7days. We can send it via HKems, HK Air Post, DHL or other methods.

We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days.

Bulk Order: Shipped via sea or air, it's according to your requirement, delivery time is 7-15days after payment.

If you have any other questions to consult me,please not hesitate to contact me any times.

Details

In vitro studies; Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT and nuclear factor-κB, leading to activation and inhibition of key genes involved in the inflammatory response. Dexamethasone effectively inhibits the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) from A549 cells with an EC50 of 2.2 nM. It was found that dexamethasone (EC50 = 36nM) -induced β2 receptor transcription is associated with glucocorticoid receptor (GR) DNA binding and occurs at concentrations that are 10-100 times higher than the inhibition of GM-CSF release. Dexamethasone (IC50 = 0.5 nM) inhibits 3 × κB (NF-κB, IκBα and I-κBβ), which is related to inhibition of GM-CSF release.

In vivo studies ;Dexamethasone at a dose of 2 × 5 mg / kg has been previously reported to effectively inhibit lipopolysaccharide (LPS) -induced inflammation. In our experimental system, single-dose dexamethasone 10 mg / kg (ip) treatment significantly reduced granulocyte recruitment and spontaneous oxygen free radicals compared to animals exposed to LPS and injected with solvent (saline) only. produce. The effect was statistically significant when administered 1 hour before and 1 hour after inhalation of LPS. The number of granulocytes in BALF drops to a level comparable to healthy animals (given aerosol). Rats treated with dexamethasone consumed less food and weighed less than control rats. Although their food intake was similar, the treated rats were also lighter than the pair-fed animals. A 5-day dexamethasone injection resulted in a significant increase in liver mass (+ 42%) and liver-to-body weight ratio (+ 65%). After 5 days of treatment, the wet weight of the gastrocnemius muscle was reduced by 20%, but it remained unaffected relative to body weight (g / 100 g body weight), indicating that muscle weight loss paralleled weight loss

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Dexamethasone CAS NO.50-02-2

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