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Home > Products >  Dihydromyricetin,Ampelopsin,Ampeloptin

Dihydromyricetin,Ampelopsin,Ampeloptin CAS NO.27200-12-0

  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,Other
  • Product Details

Keywords

  • Dihydromyricetin
  • Ampelopsin
  • Ampeloptin

Quick Details

  • ProName: Dihydromyricetin,Ampelopsin,Ampeloptin
  • CasNo: 27200-12-0
  • Molecular Formula: C15H12O8
  • Appearance: white powder
  • Application: Dihydromyricetin is a potent dihydropy...
  • DeliveryTime: 4-15 workdays
  • PackAge: 25kg per bag
  • Port: Any China port
  • ProductionCapacity: 500 Metric Ton/Week
  • Purity: >98%
  • Storage: keep in cool and dry
  • Transportation: by sea or air
  • LimitNum: 1 Kilogram
  • Grade: Pharma Grade

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Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so you can trust us.

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Details

 

Dihydromyricetin Basic information
Product Name: Dihydromyricetin
Synonyms: 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on;3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol;3,3’,4’,5,5’,7-hexahydroxy-flavanon;ampelopsin(flavanol);ampeloptin;DIHYDROMYRICETIN(RG);(+)-Dihydromyricetin;(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
CAS: 27200-12-0
MF: C15H12O8
MW: 320.25
EINECS: 200-001-8
Product Categories: Flavanones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors
Mol File: 27200-12-0.mol
Dihydromyricetin Chemical Properties
storage temp.  20°C
solubility  DMSO: ≥5mg/mL (warmed)
color  white to beige
InChIKey KJXSIXMJHKAJOD-LSDHHAIUSA-N
 
Safety Information
Safety Statements  24/25
HS Code  29329990
Dihydromyricetin Basic information
Product Name: Dihydromyricetin
Synonyms: 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on;3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol;3,3’,4’,5,5’,7-hexahydroxy-flavanon;ampelopsin(flavanol);ampeloptin;DIHYDROMYRICETIN(RG);(+)-Dihydromyricetin;(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
CAS: 27200-12-0
MF: C15H12O8
MW: 320.25
EINECS: 200-001-8
Product Categories: Flavanones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors
Mol File: 27200-12-0.mol
Dihydromyricetin Structure
 
Dihydromyricetin Chemical Properties
storage temp.  20°C
solubility  DMSO: ≥5mg/mL (warmed)
color  white to beige
InChIKey KJXSIXMJHKAJOD-LSDHHAIUSA-N
 
Safety Information
Safety Statements  24/25
HS Code  29329990
Dihydromyricetin bioactivity
Description Dihydromyricetin is a potent dihydropyrimidinase inhibitor with an IC50 of 48 μM. Dihydromyricetin activates autophagy by inhibiting the mTOR signal. Dihydromyricetin inhibits the formation of the mTOR complex (mTORC1/2).
Related category
Signal Pathway >> Autophagy >> Autophagy
Research Fields >> Cancer
Natural Products >> Flavonoids
Target
Dihydropyrimidinase: 48 μM (IC50)
 
mTORC1
 
mTORC2
 
Autophagy
 
In vitro studies Dihydromyricetin, a flavonol, significantly inhibits the catalytic activity of dihydropyrimidinase on the natural substrate dihydrouracil and the isoform substrate 5-propyl-hydantoin. Dihydromyricetin showed a significant inhibitory effect on the activity of dihydropyrimidin on both substrates, and even more inhibited than myricetin. The IC50 values ??of dihydromyricetin to dihydropyrimidin determined using a titration curve of dihydrouracil and 5-propylhydantoin were 48±2 and 40±2 μM, respectively [1]. During D-gal administration, dihydromyricetin (DHM) supplementation significantly reversed the increase in mTOR phosphorylation on Ser2448 (p-mTOR), suggesting that dihydromyricetin can activate autophagy by inhibiting mTOR signaling [ 2].
In vivo studies were evaluated by Morris water maze (MWM) in the normal control group, D-gal group, D-gal + dihydromyricetin (100 mg / kg) group, D-gal + dihydromyricetin (200 mg / kg) group. Changes in learning and memory in rats) (n = 10 per group). Compared with the D-gal-induced model group, dihydromyricetin (DHM) treatment significantly shortened the escape latency [2].
Solubility
in vitro:
DMSO: ≥100mg / mL (312.26 mM)
 
* “≥” means soluble, but the saturation is unknown.
 
In vivo: 1. Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline) Solubility: ≥2.5 mg / mL (7.81 mM); clear solution 2. Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline solubility: ≥ 2.5 mg / mL (7.81 mM); clear solution 3. Add each solvent one by one: 10% DMSO 90% corn oil Solubility: ≥ 2.5 mg / mL (7.81 mM); Clear solution
Stock solution
1 mM 3.1226 mL 15.6128 mL 31.2256 mL
5 mM 0.6245 mL 3.1226 mL 6.2451 mL
10 mM 0.3123 mL 1.5613 mL 3.1226 m

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