China (Mainland)
- Product Details
Keywords
- Sodium Chloride
- Rapamycin
- titanium dioxide
Quick Details
- ProName: Rapamycin CAS NO.53123-88-9
- CasNo: 53123-88-9
- Molecular Formula: C51H79NO13
- Appearance: Colorless tripartite crystal or diamon...
- Application: used in the manufacture of weed killin...
- DeliveryTime: Within one week
- PackAge: 1kgor 5kg/bag, 25kg/drum
- Port: any port in china
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%min
- Storage: keep dry
- Transportation: by express , by sir , by sea etc.
- LimitNum: 5 Gram
- Grade: Industrial Grade,Food Grade
Superiority
Details
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Product Name: |
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Synonyms: |
AY 22989;23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE;NSC-226080;RAPA;RAPAMUNE;RAPAMYCIN;RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS;RPM |
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MF: |
C51H79NO13 |
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MW: |
914.18 |
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EINECS: |
262-640-9 |
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Product Categories: |
Active Pharmaceutical Ingredients;Immunosuppressant;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cytokine signaling;Signalling;API;Chiral Reagents;Heterocycles;Inhibitor;VIVACTIL;antibiotic |
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Mol File: |
Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP(RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is
potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.