Allantoin for cosmetic CAS NO.97-59-6

Min.Order: 1 Kilogram
Payment Terms: T/T,MoneyGram,Other

Product Details

Keywords

allantoin
Allantol
Alantan

Quick Details

ProName: Allantoin for cosmetic
CasNo: 97-59-6
Molecular Formula: C4H6N4O3
Appearance: white powder
Application: Skin conditioner to stimulate the grow...
DeliveryTime: 3-13days
PackAge: 1kg/bag,10kg/bag or as per customer's ...
Port: Tianjin Shanghai
ProductionCapacity: 600 Metric Ton/Week
Purity: 95 96 97 98
Storage: 1. Store in a cool, ventilated warehou...
Transportation: by sea or air
LimitNum: 1 Kilogram
Grade: Pharma Grade

Superiority

1,Best Quality:

Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so you can trust us.

2, Payment method: for example T/T, Westerm Union,other

3, Excellent Service: Best service and after-sales service to all clients.

1)We will ship the goods within 5days after get your payments.If you want to cancel or change order, please tell me within 24hours after you finish the payment..

2)We will ship the goods that you order from us by DHL, UPS, TNT and EUB.We will decided to choose which courier depend on different countries.To find the best way to delivery the goods for you.

3)As usual you can get the goods with in 4-7days.If the goods were lost or not received for other reasons, please contact us immediately.

4,Fast and safe delivery:

Sample Order : As usual you can get the goods within 4-7days. We can send it via HKems, HK Air Post, DHL or other methods.

We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days.

Bulk Order: Shipped via sea or air, it's according to your requirement, delivery time is 7-15days after payment.

If you have any other questions to consult me,please not hesitate to contact me any times.

Details

Allantoin bioactivity

Description Allantoin is a skin conditioner that promotes skin health and stimulates the growth of fresh and healthy tissues.

Related categories

Signaling pathway >> G protein coupled receptor / G protein >> Imidazoline receptor

Signaling Pathway >> Neural Signaling Pathway >> Imidazoline Receptor

Natural products >> Others

Research Areas >> Cancer

Research Areas >> Inflammation / Immune

Target

Human Endogenous Metabolite

In vitro studies Allantoin is a well-known cosmetic ingredient reported to have antioxidant and anti-inflammatory activity [1]. Allantoin attenuates apoptosis and cytotoxicity in a dose-dependent manner and increases the viability of β cells induced by STZ. Allantoin reduces the level of caspase-3 and increases the level of phosphorylated B-cell lymphoma 2 (Bcl-2) expression. Allantoin has been shown to activate imidazoline 3 (I3) receptors [2].

In vivo studies Subchronic administration of allantoin (1, 3 or 10 mg / kg for 7 days) significantly increased the latency measured during scopolamine-induced cholinergic blockade and passive avoidance tasks in normal naive mice. Allantoin treatment (3 or 10 mg / kg for 7 days) also increased phosphorylated phosphatidylinositol 3-kinase (PI3K), phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK -3β) expression level. Allantoin significantly increased neuronal proliferation of immature neurons in the dentate gyrus of the hippocampus [1]. Injecting allantoin for 8 days in STZ-treated rats can significantly reduce plasma glucose and increase plasma insulin levels [2]. Allantoin lowers SHR blood pressure at 30 minutes, which is the most effective time. In addition, this antihypertensive effect was shown in a dose-dependent manner from SHR treated with allantoin. In addition, in anesthetized rats, allantoin can inhibit myocardial contractility and heart rate. In addition, allantoin significantly increased peripheral blood flow [3].

Cell experiment 30 minutes before adding 5 mM STZ, pancreatic β-cells were treated with 1,10,100 μM allantoin and incubated for 6 hours. The cell viability was measured using the ApoTox-Glo triplex assay [2].

Animal experiments Rats: Randomly divide the animals into four groups: (I) vehicle-treated control group, saline; (II) allantoin group treated with intravenous allantoin 0.5 mg / kg; (III) allantoin + The efaroxan group treated allantoin with the most effective dose (0.5mg / kg, iv) and effective dose (1.5mg / kg, iv) of efaroxan 30 minutes before the injection of allantoin; The time required for the treatment of the group by intravenous injection of different doses of allantoin. After treatment of allantoin, the rats were placed in a stent to measure the average blood pressure [3]. Mice: For the memory improvement study, mice were given vehicle solution, allantoin (1, 3 or 10 mg / kg, oral) or donepezil (5 mg / kg, oral) (10: 00-12: 00) and the same Place 7 days. For memory enhancement studies, mice were given a vehicle solution, allantoin (1, 3 or 10 mg / kg, orally) or piracetam (200 mg / kg, ip). The final administration of allantoin, donepezil or piracetam was performed 1 hour before the trial of obtaining the passive avoidance task.

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Allantoin for cosmetic CAS NO.97-59-6

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